The Neurobiological Mechanisms of Action of Spravato and Esketamine in Depression Treatment
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Introduction: Depression is a complex mental health disorder that affects millions of people worldwide. Traditional antidepressant medications often take weeks to produce noticeable effects. However, recent advancements in neuroscience have led to the development of novel treatments, such as Spravato (esketamine), which offer rapid relief for individuals with depression. This article aims to delve into the neurobiological mechanisms of action of Spravato and esketamine, shedding light on how these medications work to alleviate symptoms of depression. Understanding Depression: Depression is characterised by persistent feelings of sadness, loss of interest or pleasure, and a range of physical and cognitive symptoms. Neurotransmitters, the chemical messengers in the brain, play a crucial role in regulating mood and emotional well-being. Imbalances in neurotransmitter levels, particularly serotonin, norepinephrine, and dopamine, are often associated with depressive sympto...